The aim of this literature review is to detect the rate of the development of the antibiotic resistant bacteria and the antibiotic abuse by either the healthcare providers or the patients. Antibiotic abuse and the Resistance to antimicrobial agents is a major health problem that affects the whole world, Providing Information on the past state of antimicrobial resistance in Libya may assist the health authorities in addressing and reduce the problem more effectively in the future. Data and information were obtained from 1 article and 5 published studies about Libya by using (PubMed) and (Google scholar) using the terms ‘antibiotic resistant bacteria’ ‘multidrug resistant bacteria in developing countries’ ‘antibiotic abuse in north Africa’ however the data on Libya were very scarce. The term of multidrugresistant (MDR) is defined by the (NIH) as the acquired non susceptibility to at least one agent in three or more antimicrobial categories, other terms are extensively drug- resistant (XDR) and the pandrug-resistant (PDR) these are more devastating and dangerous to community than (MDR), the problem of the emergence of antibiotic resistance is primarily due to excessive and often unnecessary use of antibiotics in humans and animal agriculture without prescription from healthcare providers. According to the data we examined in each study they showed evidences of the multidrug resistant bacteria isolated and cultured from different sources.